In a recent case study, researchers at North Carolina State University recount an adolescent human patient diagnosed with rapid onset Schizophrenia who was found instead to have a Bartonella henselae infection. This supports the growing body of proof that Bartonella infection can mimic a multitude of chronic illnesses, including mental illness, and pave the way for new research avenues into bacterial or microbial causes of mental disorders.

Bartonella is a bacteria most frequently associated with Cat Scratch Disease, which until recently was believed to be a short-lived (or self-limiting) infection. There are no less than 30 different known species of Bartonella, and 13 of those have been identified as infecting human beings. The ability to find and diagnose Bartonella infection in animals and humans—it is renowned for “hiding” in the linings of blood vessels—has led to its identification in patients with a host of chronic illnesses ranging from Migraines to Seizures to Rheumatoid illnesses that the medical community previously hadn’t been able to assign to a exact cause.

In a case study published in the Journal of Central Nervous Disease, an adolescent with sudden onset psychotic behavior—diagnosed as Schizophrenia—was seen and treated by numerous specialists and therapists over an 18-month period. All traditional treatments for both psychosis and autoimmune disorders failed. Finally a physician recognized lesions on the patient’s skin that are often associated with Bartonella, and the patient tested positive for the infection. Combination antimicrobial chemotherapy resulted in a complete recovery.

“This case is interesting for a number of reasons,” says Dr. Ed Breitschwerdt, Melanie S. Steele Distinguished Professor of Internal Medicine at NC State and lead author of the case report. “Beyond suggesting that Bartonella infection itself could contribute to progressive neuropsychiatric disorders like Schizophrenia, it raises the question of how often infection may be involved with psychiatric disorders generally.


“Researchers are starting to look at things like infection’s role in Alzheimer’s Disease, for example. Beyond this one case, there’s a lot of movement in trying to understand the potential role of viral and bacterial infections in these medically complex diseases. This case gives us proof that there can be a connection, and offers an opportunity for future investigations.”